The involvement of central corticotropin-releasing hormone and its receptors in sleep-wake regulation of mice
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منابع مشابه
The Role of Corticotropin-releasing Hormone (crh) in Stressor-induced Alterations of Sleep in the Rat
Corticotropin-releasing hormone (CRH) mediates responses to a variety of stressors. We subjected rats to a one hour period of an acute stressor, physical restraint, and determined the impact on subsequent sleep-wake behavior. Restraint at the beginning of the light period, but not the dark period, increased waking and reduced rapid eye movements sleep (REMS) without dramatically altering slow w...
متن کاملWake-promoting effects of orexin: Its independent actions against the background of an impaired corticotropine-releasing hormone receptor system.
It is widely accepted that orexin (hypocretin) bears wake-promoting effects. While under normal conditions the circadian rhythm of orexin release has a clear circadian distribution, the amplitude of orexin fluctuation is dampened in depression. Interestingly, clinical symptoms of depression include several sleep disturbances. In this disease, corticotropin-releasing hormone (CRH) seems to be an...
متن کاملRole of corticotropin-releasing hormone in stressor-induced alterations of sleep in rat.
Corticotropin-releasing hormone (CRH) mediates responses to a variety of stressors. We subjected rats to a 1-h period of an acute stressor, physical restraint, and determined the impact on subsequent sleep-wake behavior. Restraint at the beginning of the light period, but not the dark period, increased waking and reduced rapid eye movement sleep without dramatically altering slow-wave sleep (SW...
متن کاملLateral Hypothalamus Corticotropin Releasing Hormone Receptor-1 Inhibition Modulates Stress- Induced Anxiety Behavior
Stress is a reaction to unwanted events disturbing body homeostasis which influences its pathways and target areas. Stress affects the brain through the lateral hypothalamic area (LHA) orexinergic system that mediates the effect of corticotropin-releasing hormone (CRH) through CRH receptor type 1 (CRHr1). Therefore, this study explores the outcome of stress exposure on anxiety development and t...
متن کاملIL-1 is a mediator of increases in slow-wave sleep induced by CRH receptor blockade.
We hypothesize that corticotropin-releasing hormone (CRH), a regulator of the hypothalamic-pituitary-adrenal (HPA) axis, is involved in sleep-wake regulation on the basis of observations that the CRH receptor antagonist astressin, after a delay of several hours, reduces waking and increases slow-wave sleep (SWS) in rats. This delay suggests a cascade of events that begins with the HPA axis and ...
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